A NEW STANDARD OF CARE FOR THE TREATMENT OF CHEMOTHERAPY-INDUCED DIARRHEA (CID) IN DOGS
Only FDA conditionally approved product to treat chemotherapy-induced diarrhea (CID) in dogs
“Diarrhea is a common side effect of chemotherapy in dogs, which can be so severe that cancer treatment must be halted. Chemotherapy drugs often have potential side effects..."
“Diarrhea is a common side effect of chemotherapy in dogs, which can be so severe that cancer treatment must be halted. Chemotherapy drugs often have potential side effects, but, unlike in human medicine where patients may be willing to tolerate some discomfort in exchange for a potential cure, the primary purpose of cancer treatment in dogs and other pets is to extend survival without sacrificing quality of life and comfort,” said Steven M. Solomon, D.V.M., M.P.H., director of the FDA’s Center for Veterinary Medicine. “This new medication provides veterinarians and dog owners with another tool to help control the side effects of chemotherapy for dogs undergoing such treatment.”
Steven M. Solomon, D.V.M., M.P.H., director of the FDA’s Center for Veterinary Medicine - FDA News Release
WHAT IS Canalevia-CA1?
Canalevia-CA1 normalizes fluid flow to reinstate normal function in the GI tract and is an antidiarrheal, enteric-coated tablet for oral administration. It acts locally and it is not absorbed into the blood stream, resulting in a well tolerated and non-opioid drug product.
It is naturally and sustainably harvested from the sap of a medicinal tropical plant, the Croton lechleri tree.
First in Class Anti-Diarrheal
Normalizes Fluid Flow in the Gut
Novel Mechanism
of Action
Chemotherapy-Induced
Diarrhea (CID)
Crofelemer, the active ingredient in Canalevia-CA1, acts within the lumen of the GI tract.
Canalevia-CA1
Chloride
Sodium
Chloride Channels
Gut Lining
Fluid
Canalevia-CA1
Normal
Crofelemer is an inhibitor of two chloride ion (Cl ) channels at the luminal membrane of enterocytes. These channels are responsible for the regulation of Cl influx into the lumen. Crofelemer inhibits the hypersecretion of Cl in chemotherapy-induced diarrhea and normalizes the fluid influx into the GI tract.
WHAT IS HAPPENING TO MY DOG?
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VETERINARIAN
PROVIDING COMFORT AND EASING THE BURDEN OF CHEMOTHERAPY-INDUCED DIARRHEA (CID)
IN DOGS FOR THE...
SUPPORTING CONTINUED TREATMENT
Treating CID in dogs undergoing chemotherapy prevents interruption in their treatment plan. You can keep your patient on track completing their full course of therapy.
DOG OWNER
COST AND TIME SAVINGS
Inhibiting CID in your pet reduces the incidence of accidents around the home that cause costly damages, missed days at work and future vet visits. You can spend more time caring for your pet and less time cleaning spontaneous messes.
PATIENT
QUALITY OF LIFE
CID can induce distress and suffering in sensitive animals like dogs. Alleviating CID can improve the quality of life for dogs undergoing an already traumatic experience, and reduces the chance of extra visits to the veterinarian.
KEY BENEFITS OF Canalevia-CA1
Easing the Burden
A planned CID treatment reduces costly accidents around the home, and improves the quality of life for dogs undergoing chemotherapy and their owners.
Normalizing
Reduces the instances of watery stools.
Non-Opioid
A well-tolerated treatment.
Novel MOA
Modulates the hypersecretion of CI in CID and normalizes water influx into the intestinal lumen.
Distinctive
Only FDA conditionally approved product for chemotherapy-induced diarrhea (CID) in dogs.
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Approximately 1 in 4 dogs will, at some stage in their life, develop neoplasia. 1
Alleviating CID improves the quality of life for dogs undergoing an already traumatic experience.
Canalevia-CA1 is well tolerated with only a three-day course of treatment for dogs under 140 lbs. 2
1 AVMA. “Cancer in Pets.” AVMA, www.avma.org/resources/pet-owners/petcare/cancer-pets. Accessed 21 Dec. 2021.
2. Canalevia®-CA1 [package insert]. San Francisco, CA: Jaguar Animal Health, Inc; March 2022.