Golden Retriever, Senior Dog, Companion Dog, Dog Owners, Dog Diginity, Treatment of Chemotherapy-Induced Diarrhea In Dogs, CID

A NEW STANDARD OF CARE FOR THE TREATMENT OF CHEMOTHERAPY-INDUCED DIARRHEA (CID) IN DOGS

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Only FDA conditionally approved product to treat chemotherapy-induced diarrhea (CID) in dogs

WHAT IS Canalevia-CA1?

Canalevia-CA1 normalizes fluid flow to reinstate normal function in the GI tract and is an antidiarrheal, enteric-coated tablet for oral administration. It acts locally and it is not absorbed into the blood stream, resulting in a well tolerated and non-opioid drug product.

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It is naturally and sustainably harvested from the sap of a medicinal tropical plant, the Croton lechleri tree.

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First in Class Anti-Diarrheal

Normalizes Fluid Flow in the Gut

Novel Mechanism

of Action

Small dog breed, Senior dog, Companion dogs, Veterinarian, Vet tech, Continued treatment
Chemotherapy-Induced Diarrhea, CID, Canalevia-CA1, Chloride Ion, Chloride Ion Channel, Gut Lining, Water, Crofelemer, Active Ingredient, Lumen of the GI Tract, Luminal Membrane, Enterocytes, Hypersecretionsecretion

Chemotherapy-Induced

Diarrhea (CID)

Crofelemer, the active ingredient in Canalevia-CA1, acts within the lumen of the GI tract.

Canalevia-CA1

Chloride

Sodium

Chloride Channels

Gut Lining

Fluid

Canalevia-CA1

Normal

Crofelemer is an inhibitor of two chloride ion (Cl ) channels at the luminal membrane of enterocytes. These channels are responsible for the regulation of Cl  influx into the lumen. Crofelemer inhibits the hypersecretion of Cl  in chemotherapy-induced diarrhea and normalizes the fluid influx into the GI tract.

Mode of action, chart 2, gut lining with water sodium and chloride, CID, Chemotherapy-induced diarrhea
Mode of action, chart 1, gut lining with water
Mode of action, chart 3, gut lining with water sodium chloride and Canalevia-CA1

WHAT IS HAPPENING TO MY DOG?

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VETERINARIAN

PROVIDING COMFORT AND EASING THE BURDEN OF CHEMOTHERAPY-INDUCED DIARRHEA (CID)
IN DOGS FOR THE...

Supporting continued treatment, Golden retriever, Veterinarian, Veterinary oncologist, Treating CID

SUPPORTING CONTINUED TREATMENT

Treating CID in dogs undergoing chemotherapy prevents interruption in their treatment plan. You can keep your patient on track completing their full course of therapy.

DOG OWNER

Dog owner, Supporting continued treatment, Small dog breeds, Saving time and money at the vet, Inhibiting CID, Companion animal

COST AND TIME SAVINGS

Inhibiting CID in your pet reduces the incidence of accidents around the home that cause costly damages, missed days at work and future vet visits. You can spend more time caring for your pet and less time cleaning spontaneous messes.

PATIENT

Quality of life, Supporting continued treatment, CID, Alleviating CID, Veterinarian, Dog Paw, Family Pet, Human's best friend, Hand

QUALITY OF LIFE

CID can induce distress and suffering in sensitive animals like dogs. Alleviating CID can improve the quality of life for dogs undergoing an already traumatic experience, and reduces the chance of extra visits to the veterinarian.

Large Dog Breeds, Companion Animal, Dog Owners, Spanish Perenise, Benefits of Canalevia-CA1, Family pet, Guard dog, Human's best friend

KEY BENEFITS OF Canalevia-CA1

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Easing the Burden

 

A planned CID treatment reduces costly accidents around the home, and improves the quality of life for dogs undergoing chemotherapy and their owners.

Planned CID treatement, Easing the burden of chemotherapy induced diarrhea, Reducing costly accidents, Improving the quality of life for your dog
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Normalizing

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Reduces the instances of watery stools.

Reducing the instances of watery stools
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Non-Opiod, A well-tolerated treatment, Helping with a planned CID treatment for your dog

Non-Opioid

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A well-tolerated  treatment.

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Novel MOA, Mode of Action, Inhibits Hypersecretion of CI-, Chemotherapy-induced Diarrhea, Normalizes Water Influx, GI Tract

Novel MOA​

 

Modulates the hypersecretion of CI  in CID and normalizes water influx into the intestinal lumen.

Distinctive, FDA Conditionally Approved Product, Chemotherapy-induced Diarrhea in Dogs, CID, One of a kind product to ease the burden of CID

Distinctive

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Only FDA conditionally approved product for chemotherapy-induced diarrhea (CID) in dogs.

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Dog owners, Dog family, Small breed dogs, Large breed dogs, Mixed breed dogs, Easing the burden of CID, Supporting continued treatment for your dog, Quality of life, Alleviating CID
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Neoplasia, Dog owners, Pet owners, Pet care

Approximately 1 in 4 dogs will, at some stage in their life, develop neoplasia. 1

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Alleviating CID, Improving the quality of life in dogs

Alleviating CID improves the quality of life for dogs undergoing an already traumatic experience.

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Canalevia-CA1, First in class anti-diarrheal, CID, Chemotherapy-induced diarrhea, 3 Day course of treatment, Alleviating CID

Canalevia-CA1 is well tolerated with only a three-day course of treatment for dogs under 140 lbs. 2

1 AVMA. “Cancer in Pets.” AVMA, www.avma.org/resources/pet-owners/petcare/cancer-pets. Accessed 21 Dec. 2021.

2. Canalevia®-CA1 [package insert]. San Francisco, CA: Jaguar Animal Health, Inc; March 2022.