top of page
Golden Retriever Senior Dog Companion Dog Dog Owners Dog Diginity Treatment of Chemotherap

A NON-ANTIMICROBIAL OPTION FOR THE TREATMENT OF CHEMOTHERAPY-INDUCED DIARRHEA (CID) IN DOGS.

Icon_Slides-11.png

Only FDA conditionally approved product to treat chemotherapy-induced diarrhea (CID) in dogs

“Diarrhea is a common side effect of chemotherapy in dogs, which can be so severe that cancer treatment must be halted. Chemotherapy drugs often have potential side effects..."

“Diarrhea is a common side effect of chemotherapy in dogs, which can be so severe that cancer treatment must be halted. Chemotherapy drugs often have potential side effects, but, unlike in human medicine where patients may be willing to tolerate some discomfort in exchange for a potential cure, the primary purpose of cancer treatment in dogs and other pets is to extend survival without sacrificing quality of life and comfort,” said Steven M. Solomon, D.V.M., M.P.H., director of the FDA’s Center for Veterinary Medicine. “This new medication provides veterinarians and dog owners with another tool to help control the side effects of chemotherapy for dogs undergoing such treatment.”

Steven M. Solomon, D.V.M., M.P.H., director of the FDA’s Center for Veterinary Medicine - FDA News Release

December 21, 2021 "FDA Conditionally Approves First Oral Tablet to Treat Chemotherapy-Induced Diarrhea in Dogs"

WHAT IS Canalevia-CA1?

Canalevia-CA1 normalizes fluid flow to reinstate normal function in the GI tract and is an antidiarrheal, enteric-coated tablet for oral administration. It acts locally and it is not absorbed into the blood stream, resulting in a well tolerated and non-opioid drug product.

It is naturally and sustainably harvested from the sap of a medicinal tropical plant, the Croton lechleri tree.

Pill_Leaves_0622-44.webp

First in Class Anti-Diarrheal

Normalizes Fluid Flow in the Gut

Novel Mechanism

of Action

iStock-1280869192.webp

Chemotherapy-Induced

Diarrhea (CID)

Crofelemer, the active ingredient in Canalevia-CA1, acts within the lumen of the GI tract.

Canalevia-CA1

Chloride

Sodium

Chloride Channels

Gut Lining

Fluid

Canalevia-CA1

Normal

Crofelemer is an inhibitor of two chloride ion (Cl ) channels at the luminal membrane of enterocytes. These channels are responsible for the regulation of Cl  influx into the lumen. Crofelemer inhibits the hypersecretion of Cl  in chemotherapy-induced diarrhea and normalizes the fluid influx into the GI tract.

Mode of action, chart 2, gut lining with water sodium and chloride, CID, Chemotherapy-induced diarrhea
Mode of action, chart 1, gut lining with water
Mode of action, chart 3, gut lining with water sodium chloride and Canalevia-CA1

WHAT IS HAPPENING TO MY DOG?

FINAL_MOA_Consumer-41.png

-

-

-

VETERINARIAN

PROVIDING COMFORT AND EASING THE BURDEN OF CHEMOTHERAPY-INDUCED DIARRHEA (CID)
IN DOGS FOR THE...

iStock-486894272_edited_edited.jpg

SUPPORTING CONTINUED TREATMENT

Treating CID in dogs undergoing chemotherapy prevents interruption in their treatment plan. You can keep your patient on track completing their full course of therapy.

DOG OWNER

pexels-samson-katt-5257599_edited.jpg

COST AND TIME SAVINGS

Inhibiting CID in your pet reduces the incidence of accidents around the home that cause costly damages, missed days at work and future vet visits. You can spend more time caring for your pet and less time cleaning spontaneous messes.

PATIENT

pexels-blue-bird-7210698_edited.jpg

QUALITY OF LIFE

CID can induce distress and suffering in sensitive animals like dogs. Alleviating CID can improve the quality of life for dogs undergoing an already traumatic experience, and reduces the chance of extra visits to the veterinarian.

jovana-askrabic-4QQQTTXn3NA-unsplash_EDITED.webp

KEY BENEFITS OF Canalevia-CA1

Rounded_Rec-11.png

Easing the Burden

 

A planned CID treatment reduces costly accidents around the home, and improves the quality of life for dogs undergoing chemotherapy and their owners.

Planned CID treatement, Easing the burden of chemotherapy induced diarrhea, Reducing costly accidents, Improving the quality of life for your dog
Rounded_Rec-12.png

Normalizing

Reduces the instances of watery stools.

Reducing the instances of watery stools
Rounded_Rec-13.png
Non-Opiod, A well-tolerated treatment, Helping with a planned CID treatment for your dog

Non-Opioid

A well-tolerated  treatment.

Rounded_Rec-12.png
Novel MOA, Mode of Action, Inhibits Hypersecretion of CI-, Chemotherapy-induced Diarrhea, Normalizes Water Influx, GI Tract

Novel MOA

 

Modulates the hypersecretion of CI  in CID and normalizes water influx into the intestinal lumen.

Distinctive, FDA Conditionally Approved Product, Chemotherapy-induced Diarrhea in Dogs, CID, One of a kind product to ease the burden of CID

Distinctive

Only FDA conditionally approved product for chemotherapy-induced diarrhea (CID) in dogs.

Icon_LightBlue-02.png

-

SIGN UP FOR THE LATEST NEWS ABOUT Canalevia-CA1

iStock-1204289132.webp
Rounded_Rec-12.png
Neoplasia, Dog owners, Pet owners, Pet care

Approximately 1 in 4 dogs will, at some stage in their life, develop neoplasia. 1

Rounded_Rec-12.png
Alleviating CID, Improving the quality of life in dogs

Alleviating CID improves the quality of life for dogs undergoing an already traumatic experience.

Rounded_Rec-12.png
Canalevia-CA1, First in class anti-diarrheal, CID, Chemotherapy-induced diarrhea, 3 Day course of treatment, Alleviating CID

Canalevia-CA1 is well tolerated with only a three-day course of treatment for dogs under 140 lbs. 2

1 AVMA. “Cancer in Pets.” AVMA, www.avma.org/resources/pet-owners/petcare/cancer-pets. Accessed 21 Dec. 2021.

2. Canalevia®-CA1 [package insert]. San Francisco, CA: Jaguar Animal Health, Inc; March 2022.

bottom of page